As long as you’re taking PrEP as prescribed, consuming drugs and alcohol should not directly affect how well PrEP works. However, substance use may affect how consistently you take the medication, and missing doses can lower the effectiveness of PrEP.
And one important note about PrEP and inection drug use: One major study of PrEP use among injection drug users (IDUs) suggests that PrEP may not be as effective at preventing the transmission of HIV through needle, syringe, and drug-works sharing as through sex. The IDUs in the study who reported they were taking PrEP as prescribed and at least had detectable PrEP in their blood had a 74 percent reduced risk of HIV.
#AskTheHIVDoc is a video series from Greater Than AIDS featuring top HIV doctors providing answers to commonly-asked questions about HIV prevention, testing and treatment.
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